Facilities

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Facilities

[/vc_column_text][dt_gap height=”25″][vc_column_text]IntelliSyn is located at the NeoMed Institute, which is a state-of-the-art pharma research facilityfor chemistry, biology, and drug metabolism studies. We are within 5 miles from the Montreal International Airport. Our proximity to downtown Montreal facilitates collaborations with leading researchers in the pharma and academic communities and affords access to an outstanding pool of scientific talent.[/vc_column_text][dt_gap height=”40″][/vc_column][/vc_row][vc_row][vc_column width=”1/2″][vc_column_text]

Chemistry

[/vc_column_text][dt_gap height=”25″][vc_column_text]IntelliSyn’s laboratories are fully-equipped to produce compounds from milligram up to kilogram quantities. We perform a full range of synthetic and organometallic chemistries, including anhydrous/air-sensitive, microwave, and photochemical reactions. Extensive purification systems include prep and semi-prep UV and mass-triggered HPLC, CombiFlash Rf, CombiFlash Companion, Companion XL, and chiral SFC. Analytical systems include a Bruker 500 MHz NMR, Waters mass spectrometers, polarimeters, and chiral SFC.[/vc_column_text][dt_gap height=”40″][vc_column_text]

DMPK

[/vc_column_text][dt_gap height=”25″][vc_column_text]Using the in-house rodent vivarium and analytical facilities, we regularly carry out drug exposure studies (peripheral and central) and determine pharmacokinetic profiles (IV/PO/PK) in mouse and rat.[/vc_column_text][dt_gap height=”40″][vc_column_text]

Security

[/vc_column_text][dt_gap height=”25″][vc_column_text]IntelliSyn uses an internally-secured technology infrastructure with pharma-compliant data security. Our secured electronic laboratory notebooks (ELNs) system can be accessed by clients to keep up-to-date with the progress of their projects. All of our scientists have ready access to industry standard on-line literature and patent searching capabilities, such as SciFinder and scientific journals.[/vc_column_text][/vc_column][vc_column width=”1/2″][vc_column_text]

Screening

[/vc_column_text][dt_gap height=”25″][vc_column_text]IntelliSyn, in partnership with the NeoMed Institute, offers to client’s extensive capabilities and screening technologies:

  • Cellular functional screening

○      Label free screening technology (EPIC)

○      Calcium imaging (Hammamatsu FDSS7000, FLIPR 384 wells plate format)

  • Biochemical assays

○      Intracellular signalling (cAMP, IP3, beta arrestin, ERK 1/2)

  • Radioligand binding

○      GTPgS binding (SPA and Filtration)

  • Electrophysiology

○      PatchXpress

○      Q-Patch)

  • Drug mechanism of action analysis

○      Allosterism, inverse agonism, kinetics[/vc_column_text][/vc_column][/vc_row]