NEWS & EVENTS

NEWS & EVENTS.


NEWS

Canadian Society of Chemistry Conference in Quebec City on June 3 to 7, 2019. IntelliSyn is proud to host the Med Chem Symposium.  There will be an outstanding lineup of speakers from both academia and industry.  Keynote Speakers include Prof. Stephen Hanessian (UdM), Prof. Robert Young (SFU), Dr. David Powell (Chinook Therapeutics), and Dr. Kristin Burford (Xenon Pharmaceuticals).  At the conference we look forward to visiting with colleagues, collaborators, and job-seekers at all levels (we are hiring).

ACS National Meeting in Orlando on March 31 to April 4, 2019. IntelliSyn scientist Samuel Desjardins presented the team’s work on the development of a scalable, asymmetric synthesis of an important CXCR7 modulator. A key feature of the new methodology features a selective ring-opening of a transient aziridinium intermediate with cyanide and subsequent hydrolysis of a tertiary nitrile. Due the limited strategies available for the asymmetric preparation of hindered β-amino amides, they explored a representative set of hindered epoxide and amine partners to demonstrate the robustness of the approach for this otherwise challenging class. Earlier aspects related to this work have appeared in Menhaji-Klotz, et al. J. Med. Chem. 2018, 61, 3685 and Canterbury, et al. Org. Lett. 2018, 20, 5336.

Top 25 JOC articles—the ACS and the Journal of Organic Chemistry have recognized IntelliSyn scientist, Dr. Feng Zhou, together with Professor Chao-Jun Li and former colleagues, for their recent publication on Cu-catalyzed reductive arylation (J. Org. Chem., 2018, 83, 7416-7422). Their account is the 4th most highly read JOC article in 2018 and outlines a novel method that uses an inexpensive catalyst and water as a solvent to synthesize diarylethanes. This new method is robust, scalable, and insensitive to air and moisture.

IntelliSyn is pleased to announce a collaboration with Professor Sylvain Canesi at UQAM. The focus of this research is to pursue the Canesi group’s expertise in the synthesis of bioactive natural products to develop new methods toward the synthesis of novel analogs among the pancratistatins; these are small alkaloids from the amaryllidaceae family. These compounds are being investigated as a new class of drugs to treat cancer. We acknowledge support from the NSERC for funding of this work.

IntelliSyn is pleased to announce a collaboration with the Collins group from Université de Montréal via the NSERC ENGAGE grant. As such, Collins group expertise in photocatalysis to address and overcome the use of expensive and/or toxic photocatalysts, as well as expertise in flow-chemistry will simplify scale-up protocols. This will allow the synthesis of unique frameworks on scale to accelerate library development in areas of new chemical space.

IntelliSyn was awarded at the 2018 Alpha Gala of the Chamber of Commerce and Industry of Saint-Laurent – Mount Royal.

IntelliSyn is proud to sponsor the 2017-2018 Prestigious Conference at the University of Montreal. This year’s lecture on May 23rd 2018 features Professor Ilan Marek of Technion – Israel Institute of Technology, Israel.

 The organometallic catalyst Pd-PEPPSI was awarded the “2017 EROS Reagent of the Year.” This catalyst was developed by IntelliSyn scientist Dr. Adam M. Sayah during his graduate work under the direction of Prof. Michael. G. Organ at York University. This important catalyst has become widely used for challenging cross-coupling reactions. It has emerged as a leading catalyst for coupling secondary alkyl-Zinc reagents to aryl/heteroaryl halides (Negishi reactions) with excellent regioselectivity. Congratulations to Prof. Organ, Adam, and the Organ research team.

 Published review on organometallic catalysis.  The second volume in the prestigious “Science of Synthesis” series has just been published on “N-Heterocyclic Carbenes in Catalytic Organic Synthesis.” In their monograph, IntelliSyn Scientist, Dr. Michael Mulholland and his former research advisor, Prof. Shawn Collins review asymmetric reactions catalyzed by chiral N-heterocyclic carbene (NHC) complexes. They summarize the different NHC ligand types that have been developed, including both monodentate/bidentate and C1- and C2-symmetric ligands. In addition, they describe the use of such ligands in a variety of asymmetric transformations and their applications in the construction of complex molecules.

IntelliSyn Pharma is proud to sponsor the Fondation Lucien-Piché that awards scholarships to the best finishing students enrolled in undergraduate chemistry programs within the province of Quebec.

EVENTS

 IntelliSyn will be at the 2019 Canadian Society of Chemistry Conference in Quebec City on June 3 to 7 as organizer of the Medicinal Chemistry Section. The session will highlight successes and promising opportunities for young scientists interested in Canadian Med Chem and Med Chem-related research.

IntelliSyn will be participating at the ACS National Meeting in Orlando on March 31 to April 4, 2019. We look forward to meeting colleagues and friends.

IntelliSyn will be participating in the 5th Conference on the “Therapeutic Potential of Kappa Opioids” on March 28-30, 2019 at the Univ. of Washington in Seattle. Decades of intensive efforts have focused on finding drugs that modulate the kappa opioid receptor for indications including pain, mood disorders, and addiction. Recent advances in pharmacological understanding have led to renewed interest and accelerated progress on this very important pharmacological target.

 The field of PROTACs is rapidly emerging as a new therapeutic mechanism that has the potential to deliver medicines for previously undruggable targets. IntelliSyn is proud to be a co-sponsor for the SGC (Structural Genomics Institute) PROTACS symposium on March 4, 2019 in Toronto. We look forward to seeing colleagues and other researchers who are interested it the field. Please stop by and visit with us.

IntelliSyn is proud to have participated at Journée Carrière 2018 at Université de Montréal. For more information about us, visit our website.

 IntelliSyn is proud to have participated at 2018 QOMSBOC at York University this weekend. For more information about us, visit our website.

IntelliSyn will be participating at the ChemOutsourcing meeting in Long Branch, NJ on September 17-19, 2018. Stop by and visit us at Booth 109

100th Canadian Chemistry Conference and Exhibition. IntelliSyn is sponsoring and will be participating at the CSC meeting in Toronto, Canada on May 28-June 1, 2017. We will be hosting interviews for job seekers at the M.Sc. and Ph.D. levels; please contact us by email for more details.

254th American Chemical Society, IntelliSyn will be participating at the 254th ACS meeting in Washington, DC on August 20-24, 2017.

Gordon Research Conference in Medicinal Chemistry, IntelliSyn will be presenting on the design and analysis of allosteric modulators at the Gordon Research Conference at Colby-Sawyer College in New London, NH on August 6-11, 2017.

19th Royal Society of Chemistry Symposium. IntelliSyn will be participating at the RSC Med Chem Symposium in Cambridge, United Kingdom from September 10-13, 2017

Pharma ChemOutsourcing, IntelliSyn will be participating at the ChemOutsourcing meeting in Long Branch, NJ on September 18-20, 2017 and stop at Booth 117 to visit us.

8th Banff Symposium on Organic Chemistry. IntelliSyn is proud to sponsor and will be participating at the BSOC meeting in Banff, Alberta from October 27-30, 2017. We will be hosting interviews for job seekers at the M.Sc. and Ph.D. levels; please contact us by email for more details.

Proventa Drug Discovery Conference, San Francisco, USA. November 1, 2017; IntelliSyn will be presenting on Challenges and Developments in the Design of Biased-Signalling GPCR Modulators.

28th annual Quebec-Ontario Mini-Symposium for Synthetic and Bioorganic Chemistry. IntelliSyn is sponsoring and will be participating at the QOMSBOC meeting hosted by McGill University in Montreal, Canada from November 17-19, 2017. We will be hosting interviews for job seekers at the M.Sc. and Ph.D. levels; please contact us by email for more details.

 Global Medicinal Chemistry & GPCR summit. IntelliSyn is proud to be participating next week to the Global Medicinal Chemistry & GPCR summit in London, United Kingdom from November 27-28, 2017. Jeffrey Albert will be presenting on ”Emerging approaches for effective lead generation”.

 Create Continuous Flow Workshop. IntelliSyn will be participating in the Create Continuous Flow Workshop on April 17th, 2018 at the University of Montreal.

 256th American Chemical Society, IntelliSyn will be participating at the 256th ACS meeting in Boston, MA on August 19-23, 2018. In particular come see us at the following sessions: (1) “Best Practices in Fragment-Based Design”, Monday Aug 20, 9:00-11:55, (2) “Structure-Based Drug Design for GPCRs & other Difficult Targets”, Tuesday Aug 21, 1:30-5:30, and (3) “First Time Disclosure of Clinical Candidates”, Wednesday Aug 22, (9:00-11:50).

 Pharma ChemOutsourcing, IntelliSyn will be participating at the ChemOutsourcing meeting in Long Branch, NJ on September 17-19, 2018 and stop at Booth 109 to visit us.

.